Alberto Ballestrero Selected Research

Squalene Monooxygenase (Squalene Epoxidase)

11/2020	Sterol synthesis pathway inhibition as a target for cancer treatment.
1/2018	Squalene epoxidase as a promising metabolic target in cancer treatment.
1/2016	Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer.

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Alberto Ballestrero Research Topics

Disease

40	Neoplasms (Cancer) 07/2021 - 03/2003
26	Breast Neoplasms (Breast Cancer) 01/2022 - 12/2003
4	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 09/2012
4	Colorectal Neoplasms (Colorectal Cancer) 06/2019 - 03/2003
4	Leukemia 11/2015 - 11/2010
4	Inflammation (Inflammations) 06/2014 - 11/2012
3	Disease Progression 01/2021 - 02/2010
3	Rectal Neoplasms (Rectal Cancer) 03/2020 - 03/2012
3	Residual Neoplasm 01/2020 - 03/2008
3	Adenocarcinoma 01/2020 - 09/2012
3	Lymphoma (Lymphomas) 10/2018 - 02/2004
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017 - 11/2012
3	Multiple Myeloma 03/2016 - 02/2002
3	Hematologic Neoplasms (Hematological Malignancy) 02/2013 - 06/2009
3	Immune System Diseases (Immune Disorders) 01/2013 - 01/2006
2	Carcinoma (Carcinomatosis) 01/2021 - 11/2013
2	Melanoma (Melanoma, Malignant) 05/2019 - 01/2017
2	Infections 01/2019 - 10/2018
2	Heart Failure 01/2019 - 02/2006
2	Waldenstrom Macroglobulinemia (Macroglobulinemia) 10/2018 - 12/2016
2	Genomic Instability 03/2016 - 06/2014
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 09/2015 - 11/2010
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2015 - 01/2009
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2010 - 02/2010
2	Renal Cell Carcinoma (Grawitz Tumor) 09/2009 - 03/2003
1	Pathologic Complete Response 01/2022
1	Second Primary Neoplasms (Neoplasms, Second) 01/2021
1	Frailty 01/2021
1	Viral Pneumonia 01/2021
1	Sepsis (Septicemia) 01/2021
1	COVID-19 01/2021
1	Bacterial Pneumonia 01/2021
1	Lung Neoplasms (Lung Cancer) 01/2021
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2021
1	Virus Diseases (Viral Diseases) 01/2021

Drug/Important Bio-Agent (IBA)

10	NAD (NADH)IBA 01/2017 - 11/2009
8	Biomarkers (Surrogate Marker)IBA 07/2021 - 03/2012
8	Nicotinamide PhosphoribosyltransferaseIBA 01/2017 - 11/2009
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2004
6	Hormones (Hormone)IBA 01/2022 - 01/2019
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 09/2012
6	EnzymesIBA 11/2020 - 01/2013
5	Proteasome InhibitorsIBA 07/2012 - 04/2005
4	SirtuinsIBA 09/2015 - 01/2011
3	RNA (Ribonucleic Acid)IBA 01/2021 - 03/2003
3	Squalene Monooxygenase (Squalene Epoxidase)IBA 11/2020 - 01/2016
3	Histone Deacetylases (Histone Deacetylase)IBA 03/2016 - 01/2011
3	Gemcitabine FDA Link 09/2015 - 01/2009
3	N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamideIBA 09/2015 - 06/2009
3	Lapatinib (GW572016)FDA Link 05/2015 - 02/2010
2	Fulvestrant (Faslodex)FDA Link 01/2022 - 01/2020
2	Tamoxifen FDA LinkGeneric 10/2021 - 01/2020
2	Letrozole (Femara)FDA LinkGeneric 10/2021 - 01/2019
2	Estrogen ReceptorsIBA 01/2021 - 02/2010
2	bis(p-chlorophenyl)acetic acid (DDA)IBA 01/2021 - 09/2019
2	Transcription Factors (Transcription Factor)IBA 11/2020 - 02/2010
2	CholesterolIBA 11/2020 - 01/2018
2	Capecitabine (Xeloda)FDA Link 01/2020 - 03/2012
2	Antiviral Agents (Antivirals)IBA 09/2019 - 10/2018
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 09/2019 - 09/2015
2	InterferonsIBA 09/2019 - 10/2018
2	Bevacizumab (Avastin)FDA Link 06/2019 - 03/2012
2	Paclitaxel (Taxol)FDA LinkGeneric 10/2017 - 12/2003
2	Carboplatin (JM8)FDA LinkGeneric 10/2017 - 01/2009
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2017 - 06/2009
2	human ERBB2 proteinIBA 01/2017 - 04/2014
2	Adenosine Triphosphate (ATP)IBA 11/2015 - 11/2010
2	ErbB Receptors (EGF Receptor)IBA 09/2015 - 02/2013
2	Tyrosine Kinase InhibitorsIBA 05/2015 - 03/2010
2	Docetaxel (Taxotere)FDA Link 03/2014 - 10/2011
2	Messenger RNA (mRNA)IBA 02/2013 - 06/2009
2	Sirtuin 1IBA 01/2013 - 01/2011
2	CytokinesIBA 11/2012 - 01/2008
2	Bortezomib (Velcade)FDA Link 07/2012 - 01/2006
2	Neoplasm Antigens (Tumor Antigens)IBA 03/2008 - 03/2003
1	palbociclibIBA 01/2022
1	Thymidine KinaseIBA 01/2022
1	Cell-Free Nucleic AcidsIBA 07/2021
1	Immune Checkpoint InhibitorsIBA 07/2021
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2021
1	GlucansIBA 01/2021
1	PlatinumIBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2021
1	Fluconazole (Zonal)FDA LinkGeneric 01/2021
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 11/2020
1	SterolsIBA 11/2020
1	Circulating Tumor DNAIBA 01/2020
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	pyrimidineIBA 01/2020

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 01/2022 - 02/2002
9	Therapeutics 01/2022 - 06/2005
6	Neoadjuvant Therapy 01/2022 - 11/2013
6	Radiotherapy 01/2021 - 02/2004
4	Immunotherapy 07/2021 - 01/2008
2	Transplantation 04/2014 - 01/2008
1	Central Venous Catheters 01/2021
1	Vascular Access Devices (Arterial Line) 01/2021
1	Catheters 01/2021
1	Stents 01/2021